RECOVERY OF VISUAL RESPONSE OF INJURED ADULT-RAT OPTIC NERVES TREATED WITH TRANSGLUTAMINASE

被引：110

作者：

EITAN, S

SOLOMON, A

LAVIE, V

YOLES, E

HIRSCHBERG, DL

BELKIN, M

SCHWARTZ, M

机构：

[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

[2] TEL AVIV UNIV,SACKLER FAC MED,CHAIM SHEBA MED CTR,GOLDSCHLEGER EYE INST,TEL HASHOMER,ISRAEL

来源：

SCIENCE | 1994年 / 264卷 / 5166期

关键词：

D O I：

10.1126/science.7911602

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Failure of axons of the central nervous system in adult mammals to regenerate spontaneously after injury is attributed in part to inhibitory molecules associated with oligodendrocytes. Regeneration of central nervous system axons in fish is correlated with the presence of a transglutaminase. This enzyme dimerizes interleukin-2, and the product is cytotoxic to oligodendrocytes in vitro. Application of this nerve-derived transglutaminase to rat optic nerves, in which the injury had caused the loss of visual evoked potential response to light, promoted the recovery of that response within 6 weeks after injury. Transmission electron microscopy analysis revealed the concomitant appearance of axons in the distal stump of the optic nerve.

引用

页码：1764 / 1768

页数：5

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