INTERACTION OF CHROMATID BREAKS INDUCED BY NITROSOGUANIDINE IN COMBINATION WITH SOME RADIOMIMETICS AND X-RAYS

Experiments were carried out to study if chromatid breaks induced by nitrosoguanidine in combination with some known radiomimetics and X-rays interact with each other. It has been seen that nitrosoguanidine induced breaks exhibit full interaction in production of isochromatid breaks and interchanges with diepoxybutane, ethylmethane sulfonate and ethyleneimine but fail to do so with X-rays though the effects were additive. This has been interpreted to indicate that nitrosoguanidine produced aberrations have both, temporal and qualitative similarities with those of diepoxybutane, ethylmethane sulfonate and ethyleneimine and not with those induced by X-rays. © 1969 Springer-Verlag.