ESTRAMUSTINE PHOSPHATE REVERSIBLY INHIBITS AN EARLY STAGE DURING ADENOVIRUS REPLICATION

被引：3

作者：

EVERITT, E ^{[1
]}

EKSTRAND, H ^{[1
]}

BOBERG, B ^{[1
]}

HARTLEYASP, B ^{[1
]}

机构：

[1] PHARMACIA LEO THERAPEUT,HELSINGBORG,SWEDEN

来源：

ARCHIVES OF VIROLOGY | 1990年 / 111卷 / 1-2期

关键词：

D O I：

10.1007/BF01310502

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Estramustine phosphate, an estradiol-mustard conjugate, was shown to reversibly inhibit a stage during the first hour of productive adenovirus 2 infection of HeLa cells. This drug, employed in the therapy of advanced prostatic cancer, specifically interacts with microtubule-associated proteins (MAPs) of the cytoskeleton. The results obtained under physiological conditions in vivo suggest a MAPs-interference with the microtubule-mediated vectorial migration of the virus inoculum to the nucleus. Virus attachment, uncoating kinetics and the appearance of established uncoating intermediates were not affected. © 1990 Springer-Verlag.

引用

页码：15 / 28

页数：14

共 49 条

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