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PATHFINDING AND SYNAPSE FORMATION IN A ZEBRAFISH MUTANT LACKING FUNCTIONAL ACETYLCHOLINE-RECEPTORS
被引:112
作者:
WESTERFIELD, M
LIU, DW
KIMMEL, CB
WALKER, C
机构:
[1] Institute of Neuroscience University of Oregon, Eugene
来源:
关键词:
D O I:
10.1016/0896-6273(90)90139-7
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical stimulation. Moreover, we do not detect cell surface labeling by α-bungarotoxin or monoclonal antibodies that recognize the other three subunits of ACh receptors. Motoneurons, however, establish morphologically normal patterns of innervation and normal neuromuscular junctions. We suggest that neither transmitter-mediated nerve signaling nor any other aspect of ACh receptor function is required for the formation of appropriate nerve connections in this system. © 1990.
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页码:867 / 874
页数:8
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