INHIBITORS FOR THE MUTAGENICITIES OF COLON CARCINOGENS, 1,2-DIMETHYLHYDRAZINE AND AZOXYMETHANE, IN THE HOST-MEDIATED ASSAY

被引：14

作者：

MORIYA, M

OHTA, T

WATANABE, K

WATANABE, Y

SUGIYAMA, F

MIYAZAWA, T

SHIRASU, Y

机构：

[1] Toxicology Division, Institute of Environmental Toxicology, Kodaira-shi, Tokyo, 187

来源：

CANCER LETTERS | 1979年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0304-3835(79)80061-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhibitory effects of several chemicals on the mutagenicities of 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM) for Salmonella typhimurium G46 in the host-mediated assay were investigated. They were carbon disulfide (CS2), tetraethylthiuram disulfide (disulfiram, DSF), sodium diethyldithiocarbamate (SDDC), ethylene-bis(dithiocarbamato) manganese (Maneb), pyrazole (PZ), aminoacetonitrile hydrogen sulfate (AAN), and sodium selenite (SE). All the compounds, except for SE, inhibited the mutagenicities of DMH and AOM. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：325 / 330

页数：6