CDNA CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF AN OPIOID RECEPTOR WITH HIGH AFFINITIES FOR KAPPA-SUBTYPE-SELECTIVE LIGANDS

被引：96

作者：

NISHI, M

TAKESHIMA, H

FUKUDA, K

KATO, S

MORI, K

机构：

[1] INT INST ADV STUDIES,SHIMADZU N80,NISHINOKYO KUWAHARA CHO,KYOTO 604,JAPAN

[2] KYOTO UNIV HOSP,DEPT ANESTHESIA,KYOTO 60601,JAPAN

来源：

FEBS LETTERS | 1993年 / 330卷 / 01期

关键词：

OPIOID RECEPTOR; CDNA CLONING; CDNA EXPRESSION; RNA BLOT HYBRIDIZATION ANALYSIS; RAT BRAIN;

D O I：

10.1016/0014-5793(93)80923-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amino acid sequence of a rat opioid receptor, designated as ROR-D, has been deduced by cloning and sequencing the cDNA. The ROR-D expressed from the cDNA exhibits high affinities for ligands selective for the opioid receptor kappa-subtype and low affinities for ligands selective for the delta- and mu-subtypes. RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum.

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页码：77 / 80

页数：4

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