RETT-SYNDROME - THE BCL-2 GENE - A MEDIATOR OF NEUROTROPHIC MECHANISMS

被引：8

作者：

ANVERT, M ^{[1
]}

ZHANG, ZP ^{[1
]}

HAGBERG, B ^{[1
]}

机构：

[1] EAST HOSP,DEPT PEDIAT,GOTHENBURG,SWEDEN

来源：

NEUROPEDIATRICS | 1994年 / 25卷 / 06期

关键词：

RETT SYNDROME; BCL-2; APOPTOSIS;

D O I：

10.1055/s-2008-1073047

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rett syndrome affects young girls. The molecular basis is mysterious. One tenable hypothesis can be that the programmed early infantile death of neuronal cells is reprogrammed. The bcl-2 gene on chromosome 22 has been shown to play a role in the apoptosis process. No sequence abnormalities were detected in the bcl-2 gene of 6 patients with Rett syndrome which could explain the pathophysiology of Rett syndrome.

引用

页码：323 / 324

页数：2

共 11 条

[1]

AMSTRONG DD, 1992, BRIN DEV, V14, P89

[2]

ANVERT M, 1993, CLIN DEV MED, V127, P99

[3] APOPTOSIS AND DISEASE [J].