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THE INSULIN-LIKE GROWTH FACTOR-I BINDING-PROTEIN AXIS - PHYSIOLOGY, PATHOPHYSIOLOGY AND THERAPEUTIC MANIPULATION

被引：56
作者：
LANGFORD, KS [1 ]
MIELL, JP [1 ]
机构：
[1] KINGS COLL,SCH MED & DENT,ACAD DEPT MED,BESSEMER RD,LONDON SE5 9PJ,ENGLAND
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 09期
关键词：
D O I：
10.1111/j.1365-2362.1993.tb00958.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin-like growth factor-I (IGF-I) is a single-chain polypeptide which has multiple metabolic actions and effects on the differentiation and proliferation of a wide variety of cell types. IGF-I has endocrine, paracrine and autocrine actions and is bound in the circulation to a complex system of binding proteins which alter its bioavailability and activity. Thus its physiology is complex and is altered in a number of pathological states. This review will discuss these states and the actual and proposed therapeutic applications of recombinant human IGF-I (rhIGF-I).
引用
收藏
页码：503 / 516
页数：14
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