INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS, SECRETORY GRANULES AND SECRETION IN ENDOCRINE AND NEUROENDOCRINE CELLS

被引：42

作者：

BLONDEL, O

BELL, GI

SEINO, S

机构：

[1] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

[4] CHIBA UNIV,CTR BIOMED SCI,DIV MOLEC MED,CHUO KU,CHIBA 260,JAPAN

来源：

TRENDS IN NEUROSCIENCES | 1995年 / 18卷 / 04期

关键词：

D O I：

10.1016/0166-2236(95)93894-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have revealed the presence of inositol 1,4,5-trisphosphate receptors in the secretory granules of endocrine and neuroendocrine cells. This distribution suggests that inositol 1,4,5-trisphosphate-regulated release of granule stores of Ca2+ might facilitate the secretory process. In addition, inositol 1,4,5-trisphosphate receptors might participate directly in the biogenesis of secretory granules. The presence of inositol 1,4,5-trisphosphate receptors in synaptic nerve terminals raises the possibility that they might also be involved in the control of neurotransmitter release.

引用

页码：157 / 161

页数：5

共 48 条

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