1-METHYL-4-PHENYLPYRIDINIUM (MPP+) BUT NOT 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) SELECTIVELY DESTROYS DOPAMINERGIC-NEURONS IN CULTURES OF DISSOCIATED RAT MESENCEPHALIC NEURONS

被引：69

作者：

SANCHEZRAMOS, J

BARRETT, JN

GOLDSTEIN, M

WEINER, WJ

HEFTI, F

机构：

[1] UNIV MIAMI,DEPT PHYSIOL,MIAMI,FL 33101

[2] NYU MED CTR,NEW YORK,NY 10011

来源：

NEUROSCIENCE LETTERS | 1986年 / 72卷 / 02期

关键词：

D O I：

10.1016/0304-3940(86)90083-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：215 / 220

页数：6

共 20 条

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[2] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

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[6] ACUTE ADMINISTRATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) REDUCES DOPAMINE AND SEROTONIN BUT ACCELERATES NOREPINEPHRINE METABOLISM IN THE RAT-BRAIN - EFFECT OF CHRONIC PRETREATMENT WITH MPTP [J].

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[7] NEUROCHEMICAL AND HISTOCHEMICAL CHARACTERIZATION OF NEUROTOXIC EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].

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[8]

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[9]

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[10] DIFFERENCES IN THE METABOLISM OF MPTP IN THE RODENT AND PRIMATE PARALLEL DIFFERENCES IN SENSITIVITY TO ITS NEUROTOXIC EFFECTS [J].

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