INHIBITORY EFFECTS OF ENDOTHELIN-1 AND ENDOTHELIN-3 ON PROLACTIN-RELEASE - POSSIBLE INVOLVEMENT OF ENDOGENOUS ENDOTHELIN ISOPEPTIDES IN THE RAT ANTERIOR-PITUITARY

被引：23

作者：

DOMAE, M

YAMADA, K

HANABUSA, Y

FURUKAWA, T

机构：

[1] Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka

来源：

LIFE SCIENCES | 1992年 / 50卷 / 10期

关键词：

D O I：

10.1016/0024-3205(92)90474-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Spontaneous prolactin release from the isolated rat anterior pituitary was inhibited by endothelin-1 in a dose-dependent manner (10(-8)-10(-6) M). Endothelin-3 also inhibited spontaneous prolactin release with an almost identical dose-response relationship as endothelin-1. These inhibitory effects were unaffected by application of a dopamine D2-receptor antagonist, YM-09151-2 (10(-7) M). Rat anterior and posterior pituitary glands were abundant in both endothelin-1 and endothelin-3, as compared with other regions of the brain. The present results suggest that endogenous endothelin-1 and endothelin-3 in the anterior and posterior pituitary are involved in the inhibitory regulation of prolactin secretion as autocrine or paracrine factors.

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收藏

页码：715 / 722

页数：8

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