FREQUENT OVEREXPRESSION OF P53 IN DYSGERMINOMA OF THE OVARY

被引：6

作者：

DIETL, J ^{[1
]}

HORNY, HP ^{[1
]}

KAISERLING, E ^{[1
]}

机构：

[1] UNIV TUBINGEN,DEPT PATHOL,TUBINGEN,GERMANY

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1994年 / 37卷 / 02期

关键词：

DYSGERMINOMA; P53; IMMUNOHISTOCHEMISTRY;

D O I：

10.1159/000292543

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-1. Ah the tumors exhibited overexpression of p53 protein. Immunoreactive tumor cell nuclei amounted to more than 50% in 2 tumors, 10-50% in 2 tumors, and less than 10% in 3 tumors. No relationship was found between tumor stage and the degree of p53 expression. Overexpression of p53 thus appears to be very common in dysgerminoma, as it is in epithelial ovarian cancer.

引用

页码：141 / &

共 8 条

[1] P53 PROTEIN ALTERATIONS IN HUMAN TESTICULAR CANCER INCLUDING PREINVASIVE INTRATUBULAR GERM-CELL NEOPLASIA [J].