ELAM-1 MEDIATES CELL-ADHESION BY RECOGNITION OF A CARBOHYDRATE LIGAND, SIALYL-LEX

被引：1424

作者：

PHILLIPS, ML

NUDELMAN, E

GAETA, FCA

PEREZ, M

SINGHAL, AK

HAKOMORI, SI

PAULSON, JC

机构：

[1] CYTEL CORP, 11099 N TORREY PINES RD, LA JOLLA, CA 92037 USA

[2] BIOMEMBRANE INST, SEATTLE, WA 98119 USA

[3] SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

[4] UNIV WASHINGTON, DEPT PATHOBIOL & MICROBIOL, SEATTLE, WA 98195 USA

[5] SCRIPPS CLIN & RES FDN, RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA

[6] SCRIPPS CLIN & RES FDN, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA

来源：

SCIENCE | 1990年 / 250卷 / 4984期

关键词：

D O I：

10.1126/science.1701274

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAcα2,3Galβ1,4(Fucα1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.

引用

页码：1130 / 1132

页数：3

共 54 条

[21] CLONING OF GMP-140, A GRANULE MEMBRANE-PROTEIN OF PLATELETS AND ENDOTHELIUM - SEQUENCE SIMILARITY TO PROTEINS INVOLVED IN CELL-ADHESION AND INFLAMMATION [J].