CHRONIC ADMINISTRATION OF CYCLOSPORINE-A INDUCES A DECREASE IN HEPATIC EXCRETORY FUNCTION IN MAN

被引:35
作者
CADRANEL, JF
ERLINGER, S
DESRUENNE, M
LUCIANI, J
LUNEL, F
GRIPPON, P
CABROL, A
OPOLON, P
机构
[1] HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIOVASC,F-75651 PARIS,FRANCE
[2] HOP LA PITIE SALPETRIERE,UNITE TRANSPLANTAT RENALE,F-75651 PARIS,FRANCE
[3] HOP BEAUJON,SERV HEPATOL,F-92118 CLICHY,FRANCE
[4] HOP BEAUJON,INSERM,U24,F-92118 CLICHY,FRANCE
关键词
MAN; CYCLOSPORINE-A; BILIARY SECRETION; BROMOSULFOPHTHALEIN; ORGANIC ANIONS;
D O I
10.1007/BF01296488
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Chronic administration of cyclosporin A may induce cholestasis in a few patients. The purpose of this study was to examine the effect of chronic administration of cyclosporin A on serum bile acid levels, serum bilirubin concentration, and bromosulfophthalein plasmatic fractional clearance. Twenty heart-transplanted patients with normal serum alanine aminotransferase activity receiving cyclosporine A during a mean duration of 33 months (range 7-54) were compared to 20 matched kidney-transplanted patients with normal serum alanine aminotransferase receiving azathioprine for a mean duration of 34 months (range 6-72). As compared to azathioprine-treated patients, patients treated with cyclosporin A had an increase in serum bile acid levels of 32% (P < 0.01), an increase in serum bilirubin concentration of 100% (P < 0.001), and a decrease in bromosulfophthalein plasmatic fractional clearance of 60% (P < 0.001). These results suggest that cyclosporin A induces a decrease in hepatic excretory function in man.
引用
收藏
页码:1473 / 1476
页数:4
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