CHRONIC ADMINISTRATION OF CYCLOSPORINE-A INDUCES A DECREASE IN HEPATIC EXCRETORY FUNCTION IN MAN

被引：35

作者：

CADRANEL, JF

ERLINGER, S

DESRUENNE, M

LUCIANI, J

LUNEL, F

GRIPPON, P

CABROL, A

OPOLON, P

机构：

[1] HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIOVASC,F-75651 PARIS,FRANCE

[2] HOP LA PITIE SALPETRIERE,UNITE TRANSPLANTAT RENALE,F-75651 PARIS,FRANCE

[3] HOP BEAUJON,SERV HEPATOL,F-92118 CLICHY,FRANCE

[4] HOP BEAUJON,INSERM,U24,F-92118 CLICHY,FRANCE

来源：

DIGESTIVE DISEASES AND SCIENCES | 1992年 / 37卷 / 10期

关键词：

MAN; CYCLOSPORINE-A; BILIARY SECRETION; BROMOSULFOPHTHALEIN; ORGANIC ANIONS;

D O I：

10.1007/BF01296488

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic administration of cyclosporin A may induce cholestasis in a few patients. The purpose of this study was to examine the effect of chronic administration of cyclosporin A on serum bile acid levels, serum bilirubin concentration, and bromosulfophthalein plasmatic fractional clearance. Twenty heart-transplanted patients with normal serum alanine aminotransferase activity receiving cyclosporine A during a mean duration of 33 months (range 7-54) were compared to 20 matched kidney-transplanted patients with normal serum alanine aminotransferase receiving azathioprine for a mean duration of 34 months (range 6-72). As compared to azathioprine-treated patients, patients treated with cyclosporin A had an increase in serum bile acid levels of 32% (P < 0.01), an increase in serum bilirubin concentration of 100% (P < 0.001), and a decrease in bromosulfophthalein plasmatic fractional clearance of 60% (P < 0.001). These results suggest that cyclosporin A induces a decrease in hepatic excretory function in man.

引用

页码：1473 / 1476

页数：4