RECOMBINANT INTERFERON-ALPHA-2B IN THE TREATMENT OF POLYCYTHEMIA-VERA

被引：30

作者：

CIMINO, R ^{[1
]}

RAMETTA, V ^{[1
]}

MATERA, C ^{[1
]}

MELE, G ^{[1
]}

METTIVIER, V ^{[1
]}

FERRARA, F ^{[1
]}

机构：

[1] CARDARELLI GEN HOSP,DIV HEMATOL,NAPLES,ITALY

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 44卷 / 03期

关键词：

ALPHA-INTERFERON; PHLEBOTOMY; SPLENOMEGALY;

D O I：

10.1002/ajh.2830440303

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the effects of recombinant alpha2-b interferon (alpha2-b IFN) in a dose of 3 x 10(6) U intramuscularly three times a week for 1 year in 13 patients affected by polycythemia vera (PV) previously treated with phlebotomy only. Response to treatment was evaluated by reduction of the number of phlebotomies required to retain normal hematocrit value. Ten out of 13 patients (77%) responded to treatment; in 4 of them the exigency of phlebotomy was completely eliminated. In all responders a concomitant decrease of platelet count and splenomegaly was obtained. Treatment was well tolerated and side effects were easily controlled. We conclude that alpha-IFN may represent an attractive therapeutic option in the management of the proliferative stages of PV. (C) 1993 Wiley-Liss, Inc.

引用

页码：155 / 157

页数：3

共 16 条

[11]

SILVER RT, 1990, BLOOD, V76, P664

[12]

SILVER RT, 1988, BLOOD, V72, pA817

[13] HEMATOLOGIC REMISSION AND CYTOGENETIC IMPROVEMENT INDUCED BY RECOMBINANT HUMAN INTERFERON-ALPHA-A IN CHRONIC MYELOGENOUS LEUKEMIA [J].

TALPAZ, M ;

KANTARJIAN, HM ;

MCCREDIE, K ;

TRUJILLO, JM ;

KEATING, MJ ;

GUTTERMAN, JU .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (17) :1065-1069

[14]

TURRI D, 1991, HAEMATOLOGICA, V76, P75

[15]

VANTHULL E, 1978, CANCER RES, V38, P911

[16]

WADENVIK H, 1991, BLOOD, V77, P2103

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