GABA(B) ANTAGONISTS DIMINISH THE INHIBITORY GATING OF AUDITORY RESPONSE IN THE RAT HIPPOCAMPUS

被引：77

作者：

HERSHMAN, KM

FREEDMAN, R

BICKFORD, PC

机构：

[1] UNIV COLORADO, HLTH SCI CTR, DEPT PHARMACOL C236, DENVER, CO 80262 USA

[2] VET ADM MED CTR, DEPT PHARMACOL, DENVER, CO 80262 USA

[3] VET ADM MED CTR, DEPT PSYCHIAT, DENVER, CO 80262 USA

来源：

NEUROSCIENCE LETTERS | 1995年 / 190卷 / 02期

关键词：

GABA(B) RECEPTORS; HIPPOCAMPUS; INTERNEURONS; AUDITORY PHYSIOLOGY;

D O I：

10.1016/0304-3940(95)11523-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Auditory evoked responses recorded from the CA3 region of the rat hippocampus show diminished response to repeated stimuli, suggesting the activity of an inhibitory gating mechanism. The effects on this putative gating mechanism of two GABA(B) receptor antagonists, CGP35348 and CGP46381, were characterized in a conditioning testing paradigm. Both compounds, administered intracerebroventricularly, antagonized the suppression of response to the test stimulus. The results are consistent with the hypothesis that this inhibitory gating of response involves GABA(B) receptors, which may control the release of glutamate from excitatory pathways in the hippocampus.

引用

页码：133 / 136

页数：4

共 18 条

[1]

ADLER LE, 1982, BIOL PSYCHIAT, V17, P639

[2]

AULT B, 1982, J PHARMACOL EXP THER, V223, P291

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