STEREOSELECTIVE SYNTHESIS OF SYN-1,3-DIOLS

被引：18

作者：

MOHR, P

机构：

[1] Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 18期

关键词：

EPOXIDATION; SYN-1,3-DIOL; PIG LIVER ESTERASE;

D O I：

10.1016/S0040-4039(00)92213-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Z-allylsilanes 1 are epoxidized by V5+/TBHP with high erythro-selectivity (up to 97:3) . HF- or TBAF-induced fragmentation leads to syn-1,3-diols 3. Compound 3f can be transformed within two steps into a key synthon for the lactone moiety of compactin.

引用

页码：2455 / 2458

页数：4

共 13 条

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