THE USE OF MIDAZOLAM AND FLUMAZENIL IN LOCOREGIONAL ANESTHESIA - AN OVERVIEW

被引：8

作者：

HALIM, B ^{[1
]}

SCHNEIDER, I ^{[1
]}

CLAEYS, MA ^{[1
]}

CAMU, F ^{[1
]}

机构：

[1] FLEMISH FREE UNIV BRUSSELS, MED CTR, DEPT ANAESTHESIOL, LAARBACKLAAN 101, B-1090 BRUSSELS, BELGIUM

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1990年 / 34卷

关键词：

Anesthetic techniques; antagonists; benzodiazepines; flumazenil; hypnotics; locoregional anesthesia; midazolam;

D O I：

10.1111/j.1399-6576.1990.tb03181.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Midazolam is useful as an intravenous supplement to local anaesthesia techniques in producing sedation, amnesia and anxiolysis, and has about five times the sedative potency of diazepam. Considerable interpatient variability exists in dose requirements, especially in elderly patients. The combined effects of local anaesthetics and midazolam may contribute to enhanced haemodynamic effects and changes in the respiratory pattern, impairing ventilation and oxygenation. Flumazenil can be titrated in incremental doses to reverse the residual sedative effects of midazolam, without intrinsic haemodynamic or respiratory effects, but may not fully antagonise the decrease in chemoreceptor sensitivity nor the changes in breathing pattern induced by midazolam. Patients treated with epidural or spinal anaesthesia supplemented with midazolam should be monitored to avoid hypoxaemia risks even after the administration of flumazenil. © 1990 Acta Anaesthesiologica Scandinavica Fonden

引用

页码：42 / 46

页数：5