ISOLATION AND PRIMARY STRUCTURE OF A NOVEL PHEROMONOTROPIC NEUROPEPTIDE STRUCTURALLY RELATED TO LEUCOPYROKININ FROM THE ARMYWORM LARVAE, PSEUDALETIA-SEPARATA

被引：91

作者：

MATSUMOTO, S

FONAGY, A

KURIHARA, M

UCHIUMI, K

NAGAMINE, T

CHIJIMATSU, M

MITSUI, T

机构：

[1] Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, 351-01

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91765-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel pheromonotropic neuropeptide has been isolated from a head extract of the armyworm larvae, Pseudaletia separata, by a seven step purification procedure using an in vivo assay with decapitated female moths of Bombyx mori. Amino acid sequence analysis and comparison with synthetic peptides established the primary structure of the peptide, termed Pseudaletia pheromonotropin (Pss PT), as H-Lys-Leu-Ser-Tyr-Asp-Asp-Lys-Val-Phe-Glu-Asn-Val-Glu-Phe-Thr-Pro-Arg-Leu-NH2. Pss PT is structurally related to leucopyrokinin, an insect myotropic neuropeptide, and possesses the C-terminal pentapeptide, Phe-Thr-Pro-Arg-Leu-NH2, responsible for the biological activity. © 1992.

引用

页码：534 / 539

页数：6

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