DEPUDECIN - A NOVEL COMPOUND INDUCING THE FLAT PHENOTYPE OF NIH3T3 CELLS DOUBLY TRANSFORMED BY RAS-ONCOGENE AND SRC-ONCOGENE, PRODUCED BY ALTERNARIA-BRASSICICOLA

被引：47

作者：

MATSUMOTO, M ^{[1
]}

MATSUTANI, S ^{[1
]}

SUGITA, K ^{[1
]}

YOSHIDA, H ^{[1
]}

HAYASHI, F ^{[1
]}

TERUI, Y ^{[1
]}

NAKAI, H ^{[1
]}

UOTANI, N ^{[1
]}

KAWAMURA, Y ^{[1
]}

MATSUMOTO, K ^{[1
]}

SHOJI, J ^{[1
]}

YOSHIDA, T ^{[1
]}

机构：

[1] SHIONOGI & CO LTD,SHIONOGI RES LAB,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.879

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel compound depudecin inducing the flat phenotype of ras- and src-transformed NIH3T3 cells at a concentration of 1-mu-g/ml was isolated from the culture broth of Alternaria brassicicola. Based on its spectroscopic characteristics and X-ray crystallographic analysis of its bis-(1S)-(-)-camphanate, the structure of depudecin was determined to be (2R,3S,4S,5E,7S,8S,9R)-2,9-dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene.

引用

页码：879 / 885

页数：7

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