ADJUSTMENT FORMULAS FOR MATERNAL SERUM ALPHA-FETOPROTEIN, HUMAN CHORIONIC-GONADOTROPIN, AND UNCONJUGATED ESTRIOL TO MATERNAL WEIGHT AND SMOKING

被引：40

作者：

BARTELS, I

HOPPESIEVERT, B

BOCKEL, B

HEROLD, S

CAESAR, J

机构：

[1] Institute of Human Genetics, University of Göttingen

来源：

PRENATAL DIAGNOSIS | 1993年 / 13卷 / 02期

关键词：

DOWN SYNDROME; PRENATAL SCREENING; PRENATAL DIAGNOSIS; SMOKING IN PREGNANCY;

D O I：

10.1002/pd.1970130207

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Serum levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated oestriol (uE3) were measured in serum samples of 4131 non-smoking and 1018 smoking women during the second trimester of pregnancy. The levels of all three analytes decreased with increasing body weight. The AFP median was significantly increased in smokers in a dose-response association; hCG decreased by 21 per cent and uE3 decreased by 3 per cent in smokers in a non-dose-related fashion. Regression functions for adjustment of serum levels for weight and smoking should be considered in risk estimation for Down syndrome in order to give a woman's individual risk more precisely.

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页码：123 / 130

页数：8

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