NITRIC-OXIDE - A MULTIFUNCTIONAL MESSENGER SUBSTANCE IN CEREBELLAR SYNAPTIC PLASTICITY

被引：8

作者：

SHIBUKI, K ^{[1
]}

机构：

[1] RIKEN,FRONTIER RES PROGRAM,NEURAL NETWORKS LAB,WAKO,SAITAMA 35101,JAPAN

来源：

SEMINARS IN THE NEUROSCIENCES | 1993年 / 5卷 / 03期

关键词：

NITRIC OXIDE; LONG-TERM DEPRESSION; CEREBELLUM; CYCLIC GMP; LONG-TERM POTENTIATION;

D O I：

10.1016/S1044-5765(05)80055-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) signaling is required for the induction of long-term depression (LTD) in parallel fiber/Purkinje cell synapses in the cerebellum: NO is released following climbing fiber stimulation and blockade of this NO signal suppresses LTD in slices. However, NO is not obligatory for inducing LTD in cultured Purkinje cells or in slices treated with fluorocitrate, a gliotoxic metabolic inhibitor. Various possibilities about the roles of NO in cerebellar synaptic plasticity are discussed: NO may enable LTD by removing some inherent glial suppression on neural plasticity; it may work as an integrated signal producing some decision-making ability to cerebellar neural networks; and it may coordinate quick adaptation and life-time stability in cerebellar motor learning. © 1993 Academic Press Limited.

引用

页码：217 / 223

页数：7

共 43 条

[1] ARACHIDONIC-ACID INDUCES A PROLONGED INHIBITION OF GLUTAMATE UPTAKE INTO GLIAL-CELLS [J].

BARBOUR, B ;

SZATKOWSKI, M ;

INGLEDEW, N ;

ATTWELL, D .

NATURE, 1989, 342 (6252) :918-920

[2] CLIMBING FIBER ACTIVATION AND 3',5'-CYCLIC GUANOSINE MONOPHOSPHATE (CGMP) CONTENT IN CORTEX AND DEEP NUCLEI OF CEREBELLUM [J].

BIGGIO, G ;

GUIDOTTI, A .

BRAIN RESEARCH, 1976, 107 (02) :365-373

[3] NITRIC-OXIDE MEDIATES GLUTAMATE-LINKED ENHANCEMENT OF CGMP LEVELS IN THE CEREBELLUM [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :9030-9033

[4] LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].

BREDT, DS ;

HWANG, PM ;

SNYDER, SH .

NATURE, 1990, 347 (6295) :768-770

[5] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685

[6] CLONED AND EXPRESSED NITRIC-OXIDE SYNTHASE STRUCTURALLY RESEMBLES CYTOCHROME-P-450 REDUCTASE [J].

BREDT, DS ;

HWANG, PM ;

GLATT, CE ;

LOWENSTEIN, C ;

REED, RR ;

SNYDER, SH .

NATURE, 1991, 351 (6329) :714-718

[7] PAIRING OF PRESYNAPTIC AND POSTSYNAPTIC ACTIVITIES IN CEREBELLAR PURKINJE-CELLS INDUCES LONG-TERM CHANGES IN SYNAPTIC EFFICACY INVITRO [J].

CREPEL, F ;

JAILLARD, D .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 432 :123-141

[8]

Crepel F, 1990, Neuroreport, V1, P133, DOI 10.1097/00001756-199010000-00013

[9]

DEVENTE J, 1990, EUR J NEUROSCI, V2, P845

[10]

FUJITA M, 1982, BIOL CYBERN, V45, P195, DOI 10.1007/BF00336192

← 1 2 3 4 5 →