NITRIC-OXIDE - A MULTIFUNCTIONAL MESSENGER SUBSTANCE IN CEREBELLAR SYNAPTIC PLASTICITY

被引：8

作者：

SHIBUKI, K ^{[1
]}

机构：

[1] RIKEN,FRONTIER RES PROGRAM,NEURAL NETWORKS LAB,WAKO,SAITAMA 35101,JAPAN

来源：

SEMINARS IN THE NEUROSCIENCES | 1993年 / 5卷 / 03期

关键词：

NITRIC OXIDE; LONG-TERM DEPRESSION; CEREBELLUM; CYCLIC GMP; LONG-TERM POTENTIATION;

D O I：

10.1016/S1044-5765(05)80055-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) signaling is required for the induction of long-term depression (LTD) in parallel fiber/Purkinje cell synapses in the cerebellum: NO is released following climbing fiber stimulation and blockade of this NO signal suppresses LTD in slices. However, NO is not obligatory for inducing LTD in cultured Purkinje cells or in slices treated with fluorocitrate, a gliotoxic metabolic inhibitor. Various possibilities about the roles of NO in cerebellar synaptic plasticity are discussed: NO may enable LTD by removing some inherent glial suppression on neural plasticity; it may work as an integrated signal producing some decision-making ability to cerebellar neural networks; and it may coordinate quick adaptation and life-time stability in cerebellar motor learning. © 1993 Academic Press Limited.

引用

页码：217 / 223

页数：7

共 43 条

[21] CLIMBING FIBER RESPONSES IN OLIVOCEREBELLAR SLICE CULTURES .1. MICROELECTRODE RECORDINGS FROM PURKINJE-CELLS [J].

KNOPFEL, T ;

AUDINAT, E ;

GAHWILER, BH .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1990, 2 (08) :726-732

[22] BRIEF DENDRITIC CALCIUM SIGNALS INITIATE LONG-LASTING SYNAPTIC DEPRESSION IN CEREBELLAR PURKINJE-CELLS [J].

KONNERTH, A ;

DREESSEN, J ;

AUGUSTINE, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :7051-7055

[23] SYNAPTIC CURRENTS IN CEREBELLAR PURKINJE-CELLS [J].

KONNERTH, A ;

LLANO, I ;

ARMSTRONG, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2662-2665

[24] LONG-TERM DEPRESSION OF GLUTAMATE CURRENTS IN CULTURED CEREBELLAR PURKINJE NEURONS DOES NOT REQUIRE NITRIC-OXIDE SIGNALING [J].

LINDEN, DJ ;

CONNOR, JA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (01) :10-15

[25] A LONG-TERM DEPRESSION OF AMPA CURRENTS IN CULTURED CEREBELLAR PURKINJE NEURONS [J].

LINDEN, DJ ;

DICKINSON, MH ;

SMEYNE, M ;

CONNOR, JA .

NEURON, 1991, 7 (01) :81-89

[26] INFERIOR OLIVE - ITS ROLE IN MOTOR LEARNING [J].

LLINAS, R ;

WALTON, K ;

HILLMAN, DE ;

SOTELO, C .

SCIENCE, 1975, 190 (4220) :1230-1231

[27] SEQUENCE AND EXPRESSION OF A METABOTROPIC GLUTAMATE RECEPTOR [J].

MASU, M ;

TANABE, Y ;

TSUCHIDA, K ;

SHIGEMOTO, R ;

NAKANISHI, S .

NATURE, 1991, 349 (6312) :760-765

[28]

MATSUOKA I, 1992, J NEUROSCI, V12, P3350

[29] CALCIUM TRANSIENTS EVOKED BY CLIMBING FIBER AND PARALLEL FIBER SYNAPTIC INPUTS IN GUINEA-PIG CEREBELLAR PURKINJE NEURONS [J].

MIYAKAWA, H ;

LEVRAM, V ;

LASSERROSS, N ;

ROSS, WN .

JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (04) :1178-1189

[30] OCULAR DOMINANCE PLASTICITY IN ADULT CAT VISUAL-CORTEX AFTER TRANSPLANTATION OF CULTURED ASTROCYTES [J].

MULLER, CM ;

BEST, J .

NATURE, 1989, 342 (6248) :427-430

← 1 2 3 4 5 →