ASYMMETRIC HYDROLYSIS OF EPOXIDES USING AN IMMOBILIZED ENZYME PREPARATION FROM RHODOCOCCUS SP

被引：38

作者：

HECHTBERGER, P ^{[1
]}

WIRNSBERGER, G ^{[1
]}

MISCHITZ, M ^{[1
]}

KLEMPIER, N ^{[1
]}

FABER, K ^{[1
]}

机构：

[1] GRAZ TECH UNIV,INST ORGAN CHEM,STREMAYRGASSE 16,A-8010 GRAZ,AUSTRIA

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)80223-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enzyme-catalyzed asymmetric hydrolysis of epoxides was achieved using an immobilized crude enzyme preparation derived from Rhodococcus sp. (NOVO SP 409). The mechanism of the reaction was shown to occur in a trans-specific hydrolytic opening via an S(N)2-type of reaction. Depending on the substitutional pattern of the substrate, optically active epoxides and 1,2-diols with varying optical purities were obtained (in one case e.e. 72%).

引用

页码：1161 / 1164

页数：4

共 11 条

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