A CHROMOSOME SURVEY OF 2,400 NORMAL NEWBORN INFANTS

被引：137

作者：

WALZER, S

BREAU, G

GERALD, PS

机构：

[1] Clinical Genetics Division, The Children's Hospital Medical Center Boston, MA

[2] Boston Hospital for Women, Lying-In Division, Boston, MA

[3] Department of Psychiatry Harvard Medical School, Boston, MA

[4] Department of Pediatrics, Harvard Medical School, Boston, MA

来源：

JOURNAL OF PEDIATRICS | 1969年 / 74卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0022-3476(69)80202-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In order to ascertain the variety and frequency of chromosome abnormalities among normal individuals, a chromosome survey of a large number of newborn infants is in progress. This report describes the results obtained from an abbreviated chromosome analysis of 2,400 phenotypically normal newborn infants. Even though this method provides only a minimal estimate, 13 major chromosome abnormalities were observed. These included 4 instances of sex-chromosome aneuploidy and 9 instances of structural rearrangements. Two instances of the centric fusion type of D/D translocation and 3 instances of an extra, small, metacentric chromosome in addition to a normal karyotype were observed. © 1969 The C. V. Mosby Company.

引用

页码：438 / +

页数：1