REVIEW OF THE MUTAGENICITY OF ETHYLENE-OXIDE

被引：60

作者：

DELLARCO, VL

GENEROSO, WM

SEGA, GA

FOWLE, JR

JACOBSONKRAM, D

机构：

[1] US EPA, OFF HLTH RES, WASHINGTON, DC 20460 USA

[2] OAK RIDGE NATL LAB, DIV BIOL, OAK RIDGE, TN USA

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1990年 / 16卷 / 02期

关键词：

genetic risk assessment; genetic toxicology; germ cells; somatic cells;

D O I：

10.1002/em.2850160207

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Ethylene oxide has been shown to be on effective mutagen in a variety of organisms ranging from bacteria to mammalian cells. There is also an association between ethylene oxide exposure and human somatic cell cytogenetic damage. Furthermore, ethylene oxide has been shown to alkylate protein and DNA at exposure levels that have been encountered occupationally. Ethylene oxide is not only effective at producing somatic cell mutations but also at inducing genetic damage in germ cells. While it is clear that ethylene oxide is a germ cell mutagen in whole mammals, the mechanism(s) by which it produces genetic lesions in germ cells is uncertain. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：85 / 103

页数：19