THE OLIGOSACCHARIDES OF GLYCOPROTEINS - BIOPROCESS FACTORS AFFECTING OLIGOSACCHARIDE STRUCTURE AND THEIR EFFECT ON GLYCOPROTEIN PROPERTIES

被引：240

作者：

GOOCHEE, CF ^{[1
]}

GRAMER, MJ ^{[1
]}

ANDERSEN, DC ^{[1
]}

BAHR, JB ^{[1
]}

RASMUSSEN, JR ^{[1
]}

机构：

[1] GENZYME,BOSTON,MA 02111

来源：

BIO-TECHNOLOGY | 1991年 / 9卷 / 12期

关键词：

D O I：

10.1038/nbt1291-1347

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this review, we organize the recent data concerning the effects of bioprocess factors on the oligosaccharide structure of human therapeutic glycoproteins, with particular emphasis on the influence of the host cell. We also discuss the effect of oligosaccharide structure on glycoprotein properties, including antigenicity, immunogenicity and plasma clearance rate.

引用

页码：1347 / 1355

页数：9

共 114 条

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