GLUTATHIONE METABOLISM UNDER THE INFLUENCE OF HYDROPEROXIDES IN THE LACTATING MAMMARY-GLAND OF THE RAT - EFFECT OF GLUCOSE AND EXTRACELLULAR ATP

被引：2

作者：

ESTRELA, JM ^{[1
]}

MONTORO, JB ^{[1
]}

VINA, JR ^{[1
]}

VINA, J ^{[1
]}

机构：

[1] UNIV VALENCIA, FAC MED, DEPT BIOQUIM BIOL MOLEC, E-46010 VALENCIA, SPAIN

来源：

BIOSCIENCE REPORTS | 1987年 / 7卷 / 01期

关键词：

D O I：

10.1007/BF01122724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent degradation catalyzed by gamma-glutamyl transpeptidase. Low concentrations of glucose prevented the changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes. However, incubations with the peroxide, did not alter the rate of the other metabolic pathways by acini.

引用

页码：23 / 31

页数：9

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