GLUTATHIONE METABOLISM UNDER THE INFLUENCE OF HYDROPEROXIDES IN THE LACTATING MAMMARY-GLAND OF THE RAT - EFFECT OF GLUCOSE AND EXTRACELLULAR ATP

被引：2

作者：

ESTRELA, JM ^{[1
]}

MONTORO, JB ^{[1
]}

VINA, JR ^{[1
]}

VINA, J ^{[1
]}

机构：

[1] UNIV VALENCIA, FAC MED, DEPT BIOQUIM BIOL MOLEC, E-46010 VALENCIA, SPAIN

来源：

BIOSCIENCE REPORTS | 1987年 / 7卷 / 01期

关键词：

D O I：

10.1007/BF01122724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent degradation catalyzed by gamma-glutamyl transpeptidase. Low concentrations of glucose prevented the changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes. However, incubations with the peroxide, did not alter the rate of the other metabolic pathways by acini.

引用

页码：23 / 31

页数：9

共 40 条

[31]

Sies H., 1983, Functions of Glutathione: Biochemical, Physiological, Toxicological and Clinical Aspects, P51

[32] TRANSPORT OF OXIDIZED GLUTATHIONE FROM ERYTHROCYTES OF VARIOUS SPECIES IN PRESENCE OF CHROMATE [J].

SRIVASTAVA, SK ;

BEUTLER, E .

BIOCHEMICAL JOURNAL, 1969, 114 (04) :833-+

[33] STIMULATION OF HYDROLYTIC ACTIVITY AND DECREASE OF TRANSPEPTIDASE ACTIVITY OF GAMMA-GLUTAMYL TRANSPEPTIDASE BY MALEATE - IDENTITY OF A RAT-KIDNEY MALEATE-STIMULATED GLUTAMINASE AND GAMMA-GLUTAMYL TRANSPEPTIDASE [J].

TATE, SS ;

MEISTER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) :3329-3333

[34] THE INFLUENCE OF OXYGEN ON THE INDUCTION OF RADIATION-DAMAGE IN DNA IN MAMMALIAN-CELLS AFTER SENSITIZATION BY INTRACELLULAR GLUTATHIONE DEPLETION [J].

VANDERSCHANS, GP ;

VOS, O ;

ROOSVERHEIJ, WSD ;

LOHMAN, PHM .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1986, 50 (03) :453-465

[35] MAINTENANCE OF GLUTATHIONE CONTENT IN ISOLATED HEPATOCYTES [J].

VINA, J ;

HEMS, R ;

KREBS, HA .

BIOCHEMICAL JOURNAL, 1978, 170 (03) :627-630

[36] INVOLVEMENT OF GAMMA-GLUTAMYLTRANSFERASE IN AMINO-ACID-UPTAKE BY THE LACTATING MAMMARY-GLAND OF THE RAT [J].

VINA, J ;

PUERTES, IR ;

ESTRELA, JM ;

VINA, JR ;

GALBIS, JL .

BIOCHEMICAL JOURNAL, 1981, 194 (01) :99-102

[37] EFFECT OF SPECIFIC-INHIBITION OF GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE ON AMINO-ACID-UPTAKE BY MAMMARY-GLAND OF THE LACTATING RAT [J].

VINA, J ;

PUERTES, IR ;

MONTORO, JB ;

VINA, JR .

FEBS LETTERS, 1983, 159 (1-2) :119-122

[38] ROLE OF PROLACTIN IN AMINO-ACID-UPTAKE BY THE LACTATING MAMMARY-GLAND OF THE RAT [J].

VINA, J ;

PUERTES, IR ;

SAEZ, GT ;

VINA, JR .

FEBS LETTERS, 1981, 126 (02) :250-252

[39] METABOLIC INTERACTIONS OF GLUCOSE, ACETOACETATE AND INSULIN IN MAMMARY-GLAND SLICES OF LACTATING RATS [J].

WILLIAMSON, DH ;

MCKEOWN, SR ;

ILIC, V .

BIOCHEMICAL JOURNAL, 1975, 150 (02) :145-152

[40] INTEGRATION OF METABOLISM IN TISSUES OF THE LACTATING RAT [J].

WILLIAMSON, DH .

FEBS LETTERS, 1980, 117 :K93-K105

← 1 2 3 4 →