PROMOTER-OPERATOR REGION OF LAC OPERON OF ESCHERICHIA COLI

被引：110

作者：

MILLER, JH

IPPEN, K

SCAIFE, JG

BECKWITH, JR

机构：

[1] Department of Bacteriology and Immunology, Harvard Medical School, Boston

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1968年 / 38卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0022-2836(68)90395-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deletion mapping of the lac operon confirms the order i-p-o-z-y-a. The promoter and operator sites are substantially distinct from each other. The promoter region is shown to be essential for the expression of the lac operon; deletion of this region severely affects lac activity. The combined promoter-operator region between the i and z genes is much smaller than the average gene. © 1968.

引用

页码：413 / +

页数：1

共 25 条

[11] LAC OPERATOR IS DNA
GILBERT, W
MULLERHI.B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 58 (06) : 2415 - +
[12] ON INITIATION OF TRASCRIPTION OF TRYPTOPHAN OPERON IN ESCHERICHIA COLI
IMAMOTO, F
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 60 (01) : 305 - &
[13] NEW CONTROLLING ELEMENT IN LAC OPERON OF E COLI
IPPEN, K
MILLER, JH
SCAIFE, J
BECKWITH, J
[J]. NATURE, 1968, 217 (5131) : 825 - &
[14] GENETIC REGULATORY MECHANISMS IN SYNTHESIS OF PROTEINS
JACOB, F
MONOD, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1961, 3 (03) : 318 - +
[15] JONES THD, 1968, FED PROC, V27, P644
[16] FRAMESHIFT MUTATIONS IN LACTOSE OPERON OF E COLI
MALAMY, MH
[J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1966, 31 : 189 - &
[17] NONSENSE MUTANTS AND POLARITY IN LAC OPERON OF ESCHERICHIA COLI
NEWTON, WA
BECKWITH, JR
ZIPSER, D
BRENNER, S
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1965, 14 (01) : 290 - &
[18] GENETIC CONTROL AND CYTOPLASMIC EXPRESSION OF INDUCIBILITY IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY E-COLI
PARDEE, AB
JACOB, F
MONOD, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1959, 1 (02) : 165 - 178
[19] On the assay, isolation and characterization of the lac repressor
RIGGS, AD
BOURGEOIS, S
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1968, 34 (02) : 361 - 364
[20] DNA binding of the lac repressor
RIGGS, AD
BOURGEOIS, S
NEWBY, RF
COHN, M
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1968, 34 (02) : 365 - 368

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