ENVELOPED VIRUS INACTIVATION BY FATTY-ACID DERIVATIVES

被引：23

作者：

SANDS, JA ^{[1
]}

LANDIN, P ^{[1
]}

AUPERIN, D ^{[1
]}

REINHARDT, A ^{[1
]}

机构：

[1] LEHIGH UNIV,PROGRAM MOLEC BIOL,BETHLEHEM,PA 18015

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 15卷 / 01期

关键词：

D O I：

10.1128/AAC.15.1.134

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The enveloped bacteriophage Φ6 has been shown to be a valuable model system for the preliminary screening of compounds that might be expected to inactivate herpes simplex virus and other enveloped mammalian viruses. A variety of fatty acid derivatives that form fluid micelles in aqueous media have been found to be potent inactivators of Φ6. The chemical nature of the polar head group, the lenght of the alkyl chain(s), and the extent and geometry of unsaturation are all important parameters in determining the antiviral effectiveness of this class of compounds.

引用

页码：134 / 136

页数：3

共 8 条

[1] ULTRASTRUCTURE AND LIFE-CYCLE OF LIPID-CONTAINING BACTERIOPHAGE-PHI6 [J].