A functional type I interferon pathway drives resistance to cornea herpes simplex virus type 1 infection by recruitment of leukocytes

被引：37

作者：

Conrady, Christopher D. ^{[1
]}

Jones, Heather ^{[1
]}

Zheng, Min ^{[2
]}

Carr, Daniel J. J. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Immunol Microbiol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73104 USA

来源：

JOURNAL OF BIOMEDICAL RESEARCH | 2011年 / 25卷 / 02期

关键词：

herpes simplex virus type 1; type I interferon; cornea; viral infection; leukocytes; ocular immunology;

D O I：

10.1016/S1674-8301(11)60014-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Type I interferons are critical antiviral cytokines produced following herpes simplex virus type-1 (HSV-1) infection that act to inhibit viral spread. In the present study, we identify HSV-infected and adjacent uninfected corneal epithelial cells as the source of interferon-alpha. We also report mice deficient in the A1 chain of the type I IFN receptor (CD118(-/-)) are extremely sensitive to ocular infection with low doses (100 PFU) of HSV-1 as seen by significantly elevated viral titers in the cornea compared to wild type (WT) controls. The enhanced susceptibility correlated with a loss of CD4(+) and CD8(+) T cell recruitment and aberrant chemokine production in the cornea despite mounting an adaptive immune response in the draining mandibular lymph node of CD118-/- mice. Taken together, these results highlight the importance of IFN production in both the innate immune response as well as eliciting chemokine production required to facilitate adaptive immune cell trafficking.

引用

页码：111 / 119

页数：9

共 54 条

[21] REGULATION OF HERPESVIRUS MACROMOLECULAR-SYNTHESIS .1. CASCADE REGULATION OF SYNTHESIS OF 3 GROUPS OF VIRAL PROTEINS [J].

HONESS, RW ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1974, 14 (01) :8-19

[22] A NULL MUTATION IN THE GENE ENCODING A TYPE-I INTERFERON RECEPTOR COMPONENT ELIMINATES ANTIPROLIFERATIVE AND ANTIVIRAL RESPONSES TO INTERFERON-ALPHA AND INTERFERON-BETA AND ALTERS MACROPHAGE RESPONSES [J].

HWANG, SY ;

HERTZOG, PJ ;

HOLLAND, KA ;

SUMARSONO, SH ;

TYMMS, MJ ;

HAMILTON, JA ;

WHITTY, G ;

BERTONCELLO, I ;

KOLA, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11284-11288

[23] Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia [J].

Kamphuis, Elisabeth ;

Junt, Tobias ;

Waibler, Zoe ;

Forster, Reinhold ;

Kalinke, Ulrich .

BLOOD, 2006, 108 (10) :3253-3261

[24]

KLARESKOG L, 1979, INVEST OPHTH VIS SCI, V18, P310

[25] Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection [J].

Kolumam, GA ;

Thomas, S ;

Thompson, LJ ;

Sprent, J ;

Murali-Krishna, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (05) :637-650

[26]

Krawczyk A, 2010, J VIROL IN PRESS

[27] Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene [J].

Leib, DA ;

Machalek, MA ;

Williams, BRG ;

Silverman, RH ;

Virgin, HW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :6097-6101

[28] Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1 in the absence of interferon receptors [J].

Luker, GD ;

Prior, JL ;

Song, JL ;

Pica, CM ;

Leib, DA .

JOURNAL OF VIROLOGY, 2003, 77 (20) :11082-11093

[29] Type I interferons keep activated T cells alive [J].

Marrack, P ;

Kappler, J ;

Mitchell, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (03) :521-529

[30] IFN-αβ and Self-MHC Divert CD8 T Cells into a Distinct Differentiation Pathway Characterized by Rapid Acquisition of Effector Functions [J].

Marshall, Heather D. ;

Prince, Amanda L. ;

Berg, Leslie J. ;

Welsh, Raymond M. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (03) :1419-1428

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