SYNTHESIS OF SOME PURINE CARBOCYCLIC ISOSTERES OF 2',3'-DIDEOXY-3'-C-HYDROXYMETHYL NUCLEOSIDES AS POTENTIAL INHIBITORS OF HIV

被引：14

作者：

JANSON, M

SVANSSON, L

SVENSSON, SCT

KVARNSTROM, I

CLASSON, B

SAMUELSSON, B

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

[3] ASTRA HASSLE AB,S-43183 MOLNDAL,SWEDEN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 10期

关键词：

D O I：

10.1080/07328319208017820

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of some enantiomerically pure carbocyclic 2',3'-dideoxy-3'-C-hydroxymethyl derivatives of adenine, inosine and guanine is described. The Mitsunobu reaction was used in the coupling procedure giving exclusively N9-coupling. The nucleosides were tested for inhibition of HIV multiplication in vitro and were found to be inactive in the assay.

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页码：1739 / 1747

页数：9

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