FENTANYL AND PETHIDINE ARE ANTAGONISTS ON MUSCARINIC RECEPTORS IN GUINEA-PIG ILEUM

被引：13

作者：

HUSTVEIT, O

SETEKLEIV, J

机构：

[1] Department of Pharmacology, University of Oslo

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1993年 / 37卷 / 06期

关键词：

CENTRAL ANTICHOLINERGIC SYNDROME; FENTANYL; GUINEA-PIG ILEUM; MUSCARINIC RECEPTORS; PETHIDINE;

D O I：

10.1111/j.1399-6576.1993.tb03761.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In order to evaluate the anticholinergic effect of fentanyl and pethidine, the influence of these drugs on the cumulative dose-response curves of carbacholine on the guinea-pig ileum has been investigated. Fentanyl and pethidine displaced the dose-response curve for carbacholine to the right in a parallel fashion, indicating competitive antagonism. Dissociation constants determined by an agonist EC versus antagonist plot were 0.22 mumol/l for fentanyl and 1.4 mumol/l for pethidine. It is concluded that during high-dose fentanyl anaesthesia, fentanyl may bind to muscarinic receptors and thereby produce a central anticholinergic syndrome. An additional finding was that the maximal response to carbacholine increased significantly when combined with pethidine.

引用

页码：541 / 544

页数：4

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