FENTANYL AND PETHIDINE ARE ANTAGONISTS ON MUSCARINIC RECEPTORS IN GUINEA-PIG ILEUM

被引：13

作者：

HUSTVEIT, O

SETEKLEIV, J

机构：

[1] Department of Pharmacology, University of Oslo

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1993年 / 37卷 / 06期

关键词：

CENTRAL ANTICHOLINERGIC SYNDROME; FENTANYL; GUINEA-PIG ILEUM; MUSCARINIC RECEPTORS; PETHIDINE;

D O I：

10.1111/j.1399-6576.1993.tb03761.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In order to evaluate the anticholinergic effect of fentanyl and pethidine, the influence of these drugs on the cumulative dose-response curves of carbacholine on the guinea-pig ileum has been investigated. Fentanyl and pethidine displaced the dose-response curve for carbacholine to the right in a parallel fashion, indicating competitive antagonism. Dissociation constants determined by an agonist EC versus antagonist plot were 0.22 mumol/l for fentanyl and 1.4 mumol/l for pethidine. It is concluded that during high-dose fentanyl anaesthesia, fentanyl may bind to muscarinic receptors and thereby produce a central anticholinergic syndrome. An additional finding was that the maximal response to carbacholine increased significantly when combined with pethidine.

引用

页码：541 / 544

页数：4

共 23 条

[11] NALOXONE COUNTERACTS THE FAST DEVELOPMENT OF TOLERANCE TO MORPHINE IN GUINEA-PIG ILEUM [J].

HUSTVEIT, O ;

SETEKLEIV, J ;

OYE, I .

PHARMACOLOGY & TOXICOLOGY, 1992, 71 (03) :224-228

[12]

KACHUR JF, 1990, MOL PHARMACOL, V38, P836

[13]

LADINSKY H, 1988, TRENDS PHARM SCI S, V9, P44

[14]

LONGO VG, 1966, PHARMACOL REV, V18, P965

[15] EFFECT OF PETHIDINE, FENTANYL AND MORPHINE ON POSTOPERATIVE SHIVERING IN MAN [J].

PAUCA, AL ;

SAVAGE, RT ;

SIMPSON, S ;

ROY, RC .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1984, 28 (02) :138-143

[16]

PERALTA EG, 1988, TRENDS PHARM SCI S, V9, P6

[17]

RENDIG SV, 1980, J PHARMACOL EXP THER, V215, P259

[18]

RUPREHT J, 1976, ACTA ANESTH BELGICA, V2, P45

[19]

SCHILD HO, 1957, PHARMACOL REV, V9, P242

[20]

SHAUMAN O, 1940, ARCH EXP PATHOL PH, V4196, P109

← 1 2 3 →