FACTORS CONTROLLING THE SELECTIVITY OF BETA-BLOCKING DRUGS

被引：9

作者：

COLEMAN, AJ

PATERSON, DS

SOMERVILLE, AR

机构：

[1] Imperial Chemical Industries Limited, Pharmaceuticals Division, Macclesfield, Cheshire England, Alderley Park

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 07期

关键词：

D O I：

10.1016/0006-2952(79)90295-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a number ofisomeric pairs of β blockers on adenylate cyclase activation and [3H]-dihydroalprenolol binding have been examined using membrane preparations from rabbit heart and superovulated rat corpus luteum. Para isomers always show decided selectivity for heart membranes whereas meta isomers do not. There are also differences in the relationships between KI (cyclase) and K (binding) which current theory is not adequate to explain. © 1979.

引用

页码：1011 / 1013

页数：3

共 9 条

[1]

BUCKNER CK, 1974, J PHARMACOL EXP THER, V189, P616

[2]

BUCKNER CK, 1971, J PHARMACOL EXP THER, V176, P634

[3]

BUCKNER CK, 1975, J PHARMACOL EXP THER, V194, P565

[4] SELECTIVE ACTION OF BETA-ADRENOCEPTOR BLOCKING-DRUGS AND NATURE OF BETA-1 AND BETA-2 ADRENOCEPTORS [J].

COLEMAN, AJ ;

SOMERVILLE, AR .

BRITISH JOURNAL OF PHARMACOLOGY, 1977, 59 (01) :83-93

[5] BETA-ADRENERGIC-RECEPTOR OF RAT CORPUS-LUTEUM MEMBRANES [J].

COLEMAN, AJ ;

PATERSON, DS ;

SOMERVILLE, AR .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (07) :1003-1010

[6] PHARMACOLOGICAL DIFFERENTIATION OF ADRENERGIC RECEPTORS [J].

FURCHGOT.RF .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1967, 139 (A3) :553-&

[7] DIFFERENTIATION OF RECEPTOR SYSTEMS ACTIVATED BY SYMPATHOMIMETIC AMINES [J].

LANDS, AM ;

ARNOLD, A ;

MCAULIFF, JP ;

LUDUENA, FP ;

BROWN, TG .

NATURE, 1967, 214 (5088) :597-&

[8]

MAGUIRE ME, 1977, ADV CYCLIC NUCLEOTID, V8, P6

[9] USE OF FUNCTIONAL ANTAGONISM TO DETERMINE WHETHER BETA-ADRENOCEPTOR AGONISTS MUST HAVE A LOWER EFFICACY THAN ISOPRENALINE TO BE TRACHEA-ATRIA SELECTIVE INVITRO IN GUINEA-PIGS [J].

ODONNELL, SR ;

WANSTALL, JC .

BRITISH JOURNAL OF PHARMACOLOGY, 1977, 60 (02) :255-262

← 1 →