BETA-ADRENERGIC-RECEPTOR OF RAT CORPUS-LUTEUM MEMBRANES

被引：41

作者：

COLEMAN, AJ ^{[1
]}

PATERSON, DS ^{[1
]}

SOMERVILLE, AR ^{[1
]}

机构：

[1] ICI LTD, DIV PHARMACEUT, MACCLESFIELD SK10 4TG, CHESHIRE, ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 07期

关键词：

D O I：

10.1016/0006-2952(79)90294-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A comparison was made between the .beta. receptors of rabbit heart membranes and superovulated rat corpus luteum in terms of adenylate cyclase activation and [3H]dihydroalprenolol binding. Agonist activation and binding agree in rank order: isoprenaline > noradrenaline [norepinephrine] .gtoreq. adrenaline [epinephrine] > salbutamol for heart and isoprenaline > adrenaline > salbutamol > noradrenaline for corpus luteum. The .beta.1 selective blockers practolol, atenolol and ICI 89,406 [1-(2-cyanophenoxy)-3-(.beta.-phenyl-ureido-ethyl-amino)2-propanol] are less potent in the corpus luteum than in the heart. The order of potency is not the same in corpus luteum as was found in the uterus; salbutamol, a full agonist in uterus, is only a partial agonist in corpus luteum. There apparently is not a clear cut separation of receptors into classical .beta.1 and .beta.2 types.

引用

页码：1003 / 1010

页数：8

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