REGIONAL EXPRESSION OF THE NERVE GROWTH-FACTOR GENE FAMILY IN RAT-BRAIN DURING DEVELOPMENT

被引：39

作者：

KAISHO, Y ^{[1
]}

SHINTANI, A ^{[1
]}

ONO, Y ^{[1
]}

KATO, K ^{[1
]}

IGARASHI, K ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,BIOL RES LABS,YODOGAWA KU,OSAKA 532,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)90531-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The developmental expression patterns of three members (NGF, NGF-2 NT-3, and BDNF) of the NGF family in rat brain are different. NGF-2 NT-3 mRNA was the first detected during development followed by NGF and BDNF mRNAs. A substantial amount of NGF mRNA was found to be synthesized in the hippocampus and the cortex, and this regional expression pattern did not change during development. In contrast, NGF-2 NT-3 mRNA was detected in almost all the brain regions examined in the early developmental stage. In the late stage, the transcript was found in high concentration only in the hippocampus and the cerebellum. BDNF mRNA was widely distributed, and its level was augmented in the late developmental stage. © 1991.

引用

页码：379 / 385

页数：7

共 17 条

[1] PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE [J].

AVIV, H ;

LEDER, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (06) :1408-&

[2] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[3] MOLECULAR-CLONING AND NEUROTROPHIC ACTIVITIES OF A PROTEIN WITH STRUCTURAL SIMILARITIES TO NERVE GROWTH-FACTOR - DEVELOPMENTAL AND TOPOGRAPHICAL EXPRESSION IN THE BRAIN [J].

ERNFORS, P ;

IBANEZ, CF ;

EBENDAL, T ;

OLSON, L ;

PERSSON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5454-5458

[4]

GNAHN H, 1983, DEV BRAIN RES, V9, P45, DOI 10.1016/0165-3806(83)90107-4

[5] REGIONAL DISTRIBUTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN THE ADULT-MOUSE BRAIN [J].

HOFER, M ;

PAGLIUSI, SR ;

HOHN, A ;

LEIBROCK, J ;

BARDE, YA .

EMBO JOURNAL, 1990, 9 (08) :2459-2464

[6] IDENTIFICATION AND CHARACTERIZATION OF A NOVEL MEMBER OF THE NERVE GROWTH-FACTOR BRAIN-DERIVED NEUROTROPHIC FACTOR FAMILY [J].

HOHN, A ;

LEIBROCK, J ;

BAILEY, K ;

BARDE, YA .

NATURE, 1990, 344 (6264) :339-341

[7] MOLECULAR-CLONING OF A HUMAN GENE THAT IS A MEMBER OF THE NERVE GROWTH-FACTOR FAMILY [J].

JONES, KR ;

REICHARDT, LF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (20) :8060-8064

[8] CLONING AND EXPRESSION OF A CDNA-ENCODING A NOVEL HUMAN NEUROTROPHIC FACTOR [J].

KAISHO, Y ;

YOSHIMURA, K ;

NAKAHAMA, K .

FEBS LETTERS, 1990, 266 (1-2) :187-191

[9] LEVELS OF NERVE GROWTH-FACTOR AND ITS MESSENGER-RNA IN THE CENTRAL NERVOUS-SYSTEM OF THE RAT CORRELATE WITH CHOLINERGIC INNERVATION [J].

KORSCHING, S ;

AUBURGER, G ;

HEUMANN, R ;

SCOTT, J ;

THOENEN, H .

EMBO JOURNAL, 1985, 4 (06) :1389-1393

[10] MOLECULAR-CLONING AND EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR [J].

LEIBROCK, J ;

LOTTSPEICH, F ;

HOHN, A ;

HOFER, M ;

HENGERER, B ;

MASIAKOWSKI, P ;

THOENEN, H ;

BARDE, YA .

NATURE, 1989, 341 (6238) :149-152

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