BIOTIN BIOSYNTHESIS

被引：32

作者：

MARQUET, A

机构：

[1] Laboratoire de Chimie Organique Biologique - URA CNRS, place Jussieu, 75252, Paris Cédex 05

来源：

PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 06期

关键词：

D O I：

10.1351/pac199365061249

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biotin is biosynthesized in four steps from pimeloyl CoA. KAPA synthase which catalyzes the condensation fo pimeloyl CoA with alanine has been purified, kinetically characterized and its mechanism is discussed. The insertion of sulfur into dethiobiotin could be studied only in vivo. Experiments with different precursors indicate that the first step is very likely the introduction of sulfur on the methyl group, followed by cyclization.

引用

页码：1249 / 1252

页数：4