Changes in Gene Expression During Postnatal Development of the Rat Cerebellum

被引:12
作者
Bernstein, Steven L. [1 ]
Gioio, Anthony E. [1 ]
Kaplan, Barry B. [1 ]
机构
[1] Cornell Univ, Coll Med, Dept Cell Biol & Anat, 1300 York Ave, New York, NY 10021 USA
基金
美国国家卫生研究院;
关键词
gene expression; RNA-DNA hybridization; polyadenylated RNA; cerebellum; postnatal development; rat;
D O I
10.3109/01677068309107073
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The base sequence complexity of total and polysomal poly(A + )RNA from rat cerebellum was measured during postnatal development by RNA DNA hybridization. At saturation, total and polysomal poly(A +)RNA from neonate cerebellum hybridized to 12.7% and 5.0% of the single-copy genomic DNA, respectively. Assuming asymmetric transcription, the sequence complexity of these RNA populations is sufficient to code for > 100,000 different gene transcripts. The percentage of single-copy DNA expressed as total and polysomal poly(A + )RNA declined during postnatal development, reaching adult values of 10.0% and 4.1%, respectively. These results indicate that cerebellar maturation is accompanied by significant reductions in the diversity of genetic information expressed in the tissue.
引用
收藏
页码:71 / 86
页数:16
相关论文
共 38 条
[21]   IMPROVED METHOD FOR THE RAPID ISOLATION OF BRAIN RIBONUCLEIC-ACID [J].
KAPLAN, BB ;
BERNSTEIN, SL ;
GIOIO, AE .
BIOCHEMICAL JOURNAL, 1979, 183 (01) :181-184
[22]   SEQUENCE COMPLEXITY OF POLYADENYLATED RNA OBTAINED FROM RAT-BRAIN REGIONS AND CULTURED RAT CELLS OF NEURAL ORIGIN [J].
KAPLAN, BB ;
SCHACHTER, BS ;
OSTERBURG, HH ;
DEVELLIS, JS ;
FINCH, CE .
BIOCHEMISTRY, 1978, 17 (25) :5516-5524
[23]  
KAPLAN BB, 1982, HDB NEUROCHEMISTRY, V2, P1
[24]  
KAPLAN BB, 1982, MOL APPROACHES NEURO, P71
[25]   COMPARTMENTS OF PROTEIN-METABOLISM IN THE DEVELOPING BRAIN [J].
LAJTHA, A ;
DUNLOP, D ;
PATLAK, C ;
TOTH, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 561 (02) :491-501
[26]   TRANSCRIPTIONAL REGULATION IN AVIAN ERYTHROID-CELLS [J].
LASKY, L ;
TOBIN, AJ .
BIOCHEMISTRY, 1979, 18 (08) :1594-1598
[27]   NUCLEOTIDE-SEQUENCE OF RIGHTWARD OPERATOR OF PHAGE LAMBDA [J].
MANIATIS, T ;
JEFFREY, A ;
KLEID, DG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) :1184-1188
[28]   THERMAL ELUTION CHROMATOGRAPHY AND RESOLUTION OF NUCLEIC-ACIDS ON HYDROXYLAPATITE [J].
MARTINSON, HG ;
WAGENAAR, EB .
ANALYTICAL BIOCHEMISTRY, 1974, 61 (01) :144-154
[29]   RELATIONSHIP BETWEEN SIZE, STABILITY AND ABUNDANCE OF THE MESSENGER-RNA OF MOUSE L-CELLS [J].
MEYUHAS, O ;
PERRY, RP .
CELL, 1979, 16 (01) :139-148
[30]  
MORRISON MR, 1981, J BIOL CHEM, V256, P3550