CHIRAL PYRIDYL ALCOHOL-PROMOTED HIGHLY ENANTIOSELECTIVE AND RAPID ADDITION OF DIALKYLZINC TO PYRIDINECARBOXALDEHYDES

被引：18

作者：

ISHIZAKI, M ^{[1
]}

HOSHINO, O ^{[1
]}

机构：

[1] SCI UNIV TOKYO, FAC PHARMACEUT SCI, SHINJUKU KU, TOKYO 162, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 07期

关键词：

D O I：

10.1246/cl.1994.1337

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optically active 1-(2-, 3-, and 4-pyridyl)propanols and 1-(3-pyridyl)ethanol were synthesized in good to high enantiomeric excesses (up to 88% e.e.) and in a short reaction time by catalyzed asymmetric addition of dialkylzinc to pyridine-2-, 3- and 4-carboxaldehydes and 6-bromopyridine-2-carboxaldehyde in the presence of tridentate chiral 2-[2,2-dimethyl-1-(2-pyridyl)propoxy]-1,1-diarylethanols.

引用

页码：1337 / 1340

页数：4

共 23 条

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