A VOLTAGE-GATED CHLORIDE CHANNEL IN THE YEAST SACCHAROMYCES-CEREVISIAE

被引：20

作者：

HUANG, ME ^{[1
]}

CHUAT, JC ^{[1
]}

GALIBERT, F ^{[1
]}

机构：

[1] FAC MED RENNES, BIOCHEM & MOLEC BIOL LAB, CNRS, UPR 41, F-35043 RENNES, FRANCE

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1994年 / 242卷 / 04期

关键词：

OPEN READING FRAME; SEQUENCE ANALOGY; CHLORIDE CHANNEL; CHROMOSOME X; SACCHAROMYCES CEREVISIAE;

D O I：

10.1006/jmbi.1994.1607

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the sequencing and identification on chromosome X of Saccharomyces cerevisiae of an open reading frame whose product, designated yClC-1, displays significant structural similarity to a voltage-gated Cl- channel family. This putative protein contains 13 hydrophobic domains very similar to transmembrane domains exhibited by known members of this family. Some amino acids in the domains and at the loops between them are well conserved among all members. This is the first voltage-gated Cl- channel described in the yeast S. cerevisiae. The identification of yClC-1 will facilitate the functional analysis of Cl- channels in general, and should also assist in the identification of other ClC genes in higher eukaryotes.

引用

页码：595 / 598

页数：4

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