AUTOIMMUNE CHRONIC HEPATITIS EXACERBATED BY ALPHA-INTERFERON

被引：163

作者：

PAPO, T

MARCELLIN, P

BERNUAU, J

DURAND, F

POYNARD, T

BENHAMOU, JP

机构：

[1] HOP BEAUJON, SERV HEPATOL, F-92118 CLICHY, FRANCE

[2] HOP ANTOINE BECLERE, F-92140 CLAMART, FRANCE

来源：

ANNALS OF INTERNAL MEDICINE | 1992年 / 116卷 / 01期

关键词：

HEPATITIS-C; AUTOIMMUNE DISEASES; INTERFERON-ALPHA; PREDNISONE; LIVER DISEASES;

D O I：

10.7326/0003-4819-116-1-51

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe three patients with type-1 autoimmune chronic hepatitis whose liver disease was exacerbated by alpha-interferon. In all cases, chronic hepatitis was initially considered to be caused by infection with hepatitis C virus (HCV), exacerbation of disease occurred 4 to 8 weeks after alpha-interferon therapy was begun. Infection with HCV was not confirmed by second-generation specific tests. Elevated titers of antinuclear and anti-smoth-muscle antibodies were diagnostic of type-1 autoimmune chronic hepatitis. All patients showed improvement after cessation of alpha-interferon and administration of corticosteroids. Exacerbation of chronic hepatitis after treatment with alpha-interferon has practical implications. It provides a clue to the diagnosis of autoimmune chronic hepatitis, and it should prompt the cessation of alpha-interferon and the administration of corticosteroids.

引用

页码：51 / 53

页数：3

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