No evidence for dopamine-induced relaxation in isolated human mesenteric arterial strips from elderly patients

被引：3

作者：

Estan, L ^{[1
]}

MartinezMir, I ^{[1
]}

Rubio, E ^{[1
]}

MoralesOlivas, FJ ^{[1
]}

机构：

[1] UNIV VALENCIA, DEPT PHARMACOL, E-46010 VALENCIA, SPAIN

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1995年 / 26卷 / 08期

关键词：

dopamine; dopamine agonists; dopamine receptors; dopamine relaxation; isolated human artery; mesenteric artery; noradrenaline;

D O I：

10.1016/0306-3623(95)00040-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. We investigate the effects of dopamine in isolated mesenteric artery from elderly patients. 2. Noradrenaline (10(-11) to 10(-4) M) and dopamine(2.7 x 10(-6) to 1.4 x 10(-3) M) induced a concentration-dependent contraction that was antagonized by prazosin. Fenoldopam (10(-8) to 10(-4) M) and clonidine (10(-9) to 10(-4) M) did not produce any contractile effects. 3. Potassium chloride (80 mM) produced a well-maintain ed plateau contraction and dopamine-induced contraction in these conditions, which was decreased by prazosin (10(-8) M). Neither fenoldopam nor isoprenaline (10(-10) to 10(-5) M) modified the well-maintained plateau. 4. Our results suggest that post-synaptic dopamine receptors are not present in this preparation but a,adrenoceptors are present.

引用

页码：1687 / 1694

页数：8

共 46 条

[31] IDENTIFICATION AND CHARACTERIZATION OF POSTSYNAPTIC D1-DOPAMINE AND D2-DOPAMINE RECEPTORS IN THE CARDIOVASCULAR-SYSTEM [J].