STRUCTURE-ACTIVITY ANALYSIS OF A CLASS OF ORALLY ACTIVE HYDROXAMIC ACID INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

被引：63

作者：

SUMMERS, JB

GUNN, BP

MARTIN, JG

MARTIN, MB

MAZDIYASNI, H

STEWART, AO

YOUNG, PR

BOUSKA, JB

GOETZE, AM

DYER, RD

BROOKS, DW

CARTER, GW

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 10期

关键词：

D O I：

10.1021/jm00118a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1960 / 1964

页数：5

共 13 条

[1] RATIONALLY DESIGNED, POTENT COMPETITIVE INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS [J].

COREY, EJ ;

CASHMAN, JR ;

KANTNER, SS ;

WRIGHT, SW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (05) :1503-1504

[2] ACETOHYDROXAMIC ACIDS AS POTENT, SELECTIVE, ORALLY ACTIVE 5-LIPOXYGENASE INHIBITORS [J].

JACKSON, WP ;

ISLIP, PJ ;

KNEEN, G ;

PUGH, A ;

WATES, PJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (03) :499-500

[3] CHEMISTRY OF AMINE-BORANES .5. REDUCTION OF OXIMES, O-ACYL-OXIMES, AND O-ALKYL-OXIMES WITH PYRIDINE-BORANE IN ACID [J].

KAWASE, M ;

KIKUGAWA, Y .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (03) :643-645

[4] SYNTHESIS AND 5-LIPOXYGENASE INHIBITORY ACTIVITY OF 5-HYDROPEROXY-6,8,11,14-EICOSATETRAENOIC ACID ANALOGS [J].

KERDESKY, FAJ ;

SCHMIDT, SP ;

HOLMS, JH ;

DYER, RD ;

CARTER, GW ;

BROOKS, DW .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (07) :1177-1186

[5]

MACHINIST J, UNPUB

[6] SYNTHESIS OF [[(NAPHTHALENYLMETHOXY)PHENYL]AMINO]OXOALKANOIC AND [[(QUINOLINYLMETHOXY)PHENYL]AMINO]OXOALKANOIC ACID-ESTERS - A NOVEL SERIES OF LEUKOTRIENE-D4 ANTAGONISTS AND 5-LIPOXYGENASE INHIBITORS [J].

MUSSER, JH ;

KUBRAK, DM ;

CHANG, J ;

LEWIS, AJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (08) :1429-1435

[7] RELEASE OF SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS IN RAT - POLYMORPHONUCLEAR LEUKOCYTE [J].

ORANGE, RP ;

VALENTINE, MD ;

AUSTEN, KF .

SCIENCE, 1967, 157 (3786) :318-+

[8]

RAPP HJ, 1961, J PHYSL LONDON, V158, P35

[9] ORALLY ACTIVE HYDROXAMIC ACID INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS [J].

SUMMERS, JB ;

GUNN, BP ;

MARTIN, JG ;

MAZDIYASNI, H ;

STEWART, AO ;

YOUNG, PR ;

GOETZE, AM ;

BOUSKA, JB ;

DYER, RD ;

BROOKS, DW ;

CARTER, GW .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) :3-5

[10] INVIVO CHARACTERIZATION OF HYDROXAMIC ACID INHIBITORS OF 5-LIPOXYGENASE [J].

SUMMERS, JB ;

GUNN, BP ;

MAZDIYASNI, H ;

GOETZE, AM ;

YOUNG, PR ;

BOUSKA, JB ;

DYER, RD ;

BROOKS, DW ;

CARTER, GW .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (11) :2121-2126

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