ANTIARRHYTHMIC ACTIONS OF DL-SOTALOL IN VENTRICULAR AND SUPRAVENTRICULAR ARRHYTHMIAS

被引：15

作者：

SINGH, BN

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,WADSWORTH VET ADM HOSP,SCH MED,CARDIOVASC RES LAB,LOS ANGELES,CA 90073

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1992年 / 20卷

关键词：

DL-SOTALOL; EXPERIMENTAL FINDINGS; HEMODYNAMIC FINDINGS; SUPRAVENTRICULAR ARRHYTHMIAS; VENTRICULAR ARRHYTHMIAS;

D O I：

10.1097/00005344-199220002-00013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

DL-Sotalol is a unique antiarrhythmic agent combining potent beta-blocking properties with the propensity to prolong cardiac repolarization in all myocardial tissues. Its beta-blocker-associated negative inotropic effects are attenuated by its action potential-lengthening effect. The drug has an elimination half-life of 10-15 h. Sotalol's major electrophysiologic profile constitutes the summed effects of beta-blockade and prolonged repolarization. It exerts a potent antifibrillatory action modulated by its antiadrenergic effects. The effectiveness and tolerance of sotalol in a variety of atrial and ventricular dysrhythmias is reviewed in the present article.

引用

页码：S75 / S90

页数：16

共 112 条

[51] TORSADE DE POINTES INDUCED BY SOTALOL DESPITE THERAPEUTIC PLASMA SOTALOL CONCENTRATIONS [J].