Neurotropism of Human Immunodeficiency Virus

被引：31

作者：

Chiodi, Francesca ^{[1
]}

Fenyo, Eva Maria ^{[1
]}

机构：

[1] Karolinska Inst, Dept Virol, SBL, S-10521 Stockholm, Sweden

来源：

BRAIN PATHOLOGY | 1991年 / 1卷 / 03期

关键词：

D O I：

10.1111/j.1750-3639.1991.tb00658.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Three major characteristics of human immunodeficiency virus (HIV) infection define HIV as neurotropic. 1) Clinically, distinct neurological syndromes are associated with HIV infection and 2) presence of the virus as well as 3) pathological changes can be demonstrated in the central nervous system. Spread of HIV to the brain seems to be the general rule. Virus expression appears to be restricted during the asymptomatic period but increases with severity of HIV infection. Whether this reflects the emergence of virus variants with increased replicative capacity in brain cells has yet to be elucidated.

引用

页码：185 / 191

页数：7

共 58 条

[21]

FENYO EM, 1988, J VIROL, V62, P4414

[22] BIOLOGICALLY DIVERSE MOLECULAR VARIANTS WITHIN A SINGLE HIV-1 ISOLATE [J].

FISHER, AG ;

ENSOLI, B ;

LOONEY, D ;

ROSE, A ;

GALLO, RC ;

SAAG, MS ;

SHAW, GM ;

HAHN, BH ;

WONGSTAAL, F .

NATURE, 1988, 334 (6181) :444-447

[23] BIOLOGICAL CHARACTERIZATION OF INFECTIOUS MOLECULAR CLONES DERIVED FROM A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATE WITH RAPID/HIGH REPLICATIVE CAPACITY [J].

FREDRIKSSON, R ;

STALHANSKE, P ;

VONGEGERFELT, A ;

LIND, B ;

AMAN, P ;

RASSART, E ;

FENYO, EM .

VIROLOGY, 1991, 181 (01) :55-61

[24]

GAINES H, 1987, LANCET, V1, P1249

[25] HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION OF THE CENTRAL NERVOUS-SYSTEM - AN EVALUATION OF CYTOKINES IN CEREBROSPINAL-FLUID [J].

GALLO, P ;

FREI, K ;

RORDORF, C ;

LAZDINS, J ;

TAVOLATO, B ;

FONTANA, A .

JOURNAL OF NEUROIMMUNOLOGY, 1989, 23 (02) :109-116

[26]

GARDNER MB, 1985, REV INFECT DIS, V7, P99

[27] VIRUS ISOLATION FROM AND IDENTIFICATION OF HTLV-III/LAV-PRODUCING CELLS IN BRAIN-TISSUE FROM A PATIENT WITH AIDS [J].

GARTNER, S ;

MARKOVITS, P ;

MARKOVITZ, DM ;

BETTS, RF ;

POPOVIC, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1986, 256 (17) :2365-2371

[28] SECRETION OF NEUROTOXINS BY MONONUCLEAR PHAGOCYTES INFECTED WITH HIV-1 [J].

GIULIAN, D ;

VACA, K ;

NOONAN, CA .

SCIENCE, 1990, 250 (4987) :1593-1596

[29]

GOUDSMIT J, 1986, LANCET, V2, P177

[30] ISOLATION OF HTLV-III FROM CEREBROSPINAL-FLUID AND NEURAL TISSUES OF PATIENTS WITH NEUROLOGIC SYNDROMES RELATED TO THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

HO, DD ;

ROTA, TR ;

SCHOOLEY, RT ;

KAPLAN, JC ;

ALLAN, JD ;

GROOPMAN, JE ;

RESNICK, L ;

FELSENSTEIN, D ;

ANDREWS, CA ;

HIRSCH, MS .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (24) :1493-1497

← 1 2 3 4 5 6 →