BASEPAIRING WITH 18S RIBOSOMAL-RNA IN INTERNAL INITIATION OF TRANSLATION

被引：40

作者：

SCHEPER, GC

VOORMA, HO

THOMAS, AAM

机构：

[1] Department of Molecular Cell Biology, 3584 CH Utrecht

来源：

FEBS LETTERS | 1994年 / 352卷 / 03期

关键词：

PICORNAVIRUS; TRANSLATION; INTERNAL INITIATION; POLYPYRIMIDINE TRACT; 18S RIBOSOMAL RNA; BASEPAIRING;

D O I：

10.1016/0014-5793(94)00975-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In concert with the translation initiation factors 'trans-acting' factors function specifically during internal initiation on picornaviral mRNAs. Of these trans-acting factors, two have been identified as the La-protein and the polypyrimidine tract binding protein. Within the internal ribosomal entry site on the viral RNA, sequences are present that direct the ribosome to the initiation codon. We suggest that selection of the correct AUG initiation codon occurs through basepairing with a part of 18S ribosomal RNA.

引用

收藏

页码：271 / 275

页数：5

相关论文

共 36 条

[11] A CYTOPLASMIC 57-KDA PROTEIN THAT IS REQUIRED FOR TRANSLATION OF PICORNAVIRUS RNA BY INTERNAL RIBOSOMAL ENTRY IS IDENTICAL TO THE NUCLEAR PYRIMIDINE TRACT-BINDING PROTEIN [J].

HELLEN, CUT ;

WITHERELL, GW ;

SCHMID, M ;

SHIN, SH ;

PESTOVA, TV ;

GIL, A ;

WIMMER, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) :7642-7646

[12] THE INFLUENCE OF VIRAL CODING SEQUENCES ON THE EFFICIENCY OF INTERNAL INITIATION OF TRANSLATION OF CARDIOVIRUS RNAS [J].

HUNT, SL ;

KAMINSKI, A ;

JACKSON, RJ .

VIROLOGY, 1993, 197 (02) :801-807

[13] CAP-INDEPENDENT TRANSLATION OF PICORNAVIRUS RNAS - STRUCTURE AND FUNCTION OF THE INTERNAL RIBOSOMAL ENTRY SITE [J].

JANG, SK ;

PESTOVA, TV ;

HELLEN, CUT ;

WITHERELL, GW ;

WIMMER, E .

ENZYME, 1990, 44 (1-4) :292-309

[14] INITIATION OF ENCEPHALOMYOCARDITIS VIRUS-RNA TRANSLATION - THE AUTHENTIC INITIATION SITE IS NOT SELECTED BY A SCANNING MECHANISM [J].

KAMINSKI, A ;

HOWELL, MT ;

JACKSON, RJ .

EMBO JOURNAL, 1990, 9 (11) :3753-3759

[15] PRIMARY STRUCTURE, GENE ORGANIZATION AND POLYPEPTIDE EXPRESSION OF POLIOVIRUS RNA [J].

KITAMURA, N ;

SEMLER, BL ;

ROTHBERG, PG ;

LARSEN, GR ;

ADLER, CJ ;

DORNER, AJ ;

EMINI, EA ;

HANECAK, R ;

LEE, JJ ;

VANDERWERF, S ;

ANDERSON, CW ;

WIMMER, E .

NATURE, 1981, 291 (5816) :547-553

[16] AN ANALYSIS OF 5'-NONCODING SEQUENCES FROM 699 VERTEBRATE MESSENGER-RNAS [J].

KOZAK, M .

NUCLEIC ACIDS RESEARCH, 1987, 15 (20) :8125-8148

[17] ENCEPHALOMYOCARDITIS VIRUS-INFECTION OF MOUSE PLASMACYTOMA CELLS .1. INHIBITION OF CELLULAR PROTEIN-SYNTHESIS [J].

LAWRENCE, C ;

THACH, RE .

JOURNAL OF VIROLOGY, 1974, 14 (03) :598-610

[18] COMMON STRUCTURES OF THE 5' NONCODING RNA IN ENTEROVIRUSES AND RHINOVIRUSES - THERMODYNAMICAL STABILITY AND STATISTICAL SIGNIFICANCE [J].

LE, SY ;

ZUKER, M .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 216 (03) :729-741

[19] INTERACTION OF A CELLULAR 57-KILODALTON PROTEIN WITH THE INTERNAL TRANSLATION INITIATION SITE OF FOOT-AND-MOUTH-DISEASE VIRUS [J].

LUZ, N ;

BECK, E .

JOURNAL OF VIROLOGY, 1991, 65 (12) :6486-6494

[20] LA AUTOANTIGEN ENHANCES AND CORRECTS ABERRANT TRANSLATION OF POLIOVIRUS RNA IN RETICULOCYTE LYSATE [J].

MEEROVITCH, K ;

SVITKIN, YV ;

LEE, HS ;

LEJBKOWICZ, F ;

KENAN, DJ ;

CHAN, EKL ;

AGOL, VI ;

KEENE, JD ;

SONENBERG, N .

JOURNAL OF VIROLOGY, 1993, 67 (07) :3798-3807

← 1 2 3 4 →