WATER-SOLUBLE COPOLYMERS OF AN ANTIVIRAL AGENT - SYNTHESIS AND THEIR INTERACTION WITH A BIOMEMBRANE MODEL

被引：34

作者：

GIAMMONA, G ^{[1
]}

CARLISI, B ^{[1
]}

PITARRESI, G ^{[1
]}

CAVALLARO, G ^{[1
]}

LIVERI, VT ^{[1
]}

机构：

[1] UNIV PALERMO,DIPARTIMENTO CHIM FIS,I-90123 PALERMO,ITALY

来源：

JOURNAL OF CONTROLLED RELEASE | 1992年 / 22卷 / 03期

关键词：

POLYASPARTAMIDE; AMANTADINE; POLYMERIC PRODRUGS; SURFACTANT; CALORIMETRY;

D O I：

10.1016/0168-3659(92)90094-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amantadine was modified by direct acylation with succinic and glutaric anhydrides and the covalent bond with alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) was realized. The amount of amantadine in the obtained copolymers was evaluated by hydrolysis of the conjugates. The enthalpic effect due to the interaction between the two synthesized polymeric prodrugs and sodium dodecylsulphate micelles as a simple system mimicking the cellular membrane, was measured by the calorimetric technique and compared with that of PHEA. Binding of PHEA-succinylamantadine (PHEA-S-AMA) to surfactant micelles appeared to be stronger than that shown by PHEA-glutarylamantadine (PHEA-G-AMA).

引用

页码：197 / 204

页数：8

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